Mike G/Thinkstock
Most
people know that some plastics additives, such as bisphenol A (BPA),
may be harmful to their health. But an upcoming study in the journal
Environmental Health finds
that entire classes of plastics—including the type commonly referred to
as styrofoam and a type used in many baby products—may wreak havoc on
your hormones regardless of what additives are in them.
The study's authors tested 14 different BPA-free plastic resins, the
raw materials used to make plastic products, and found that four of them
released chemicals that mimic the female hormone estrogen. That's not
surprising. As
Mother Jones reported
earlier this year,
many BPA-free plastic goods—from baby bottles and sippy cups to
food-storage containers—leach potentially harmful estrogenlike
chemicals.
But until now, it wasn't clear what role the resins played.
The new study suggests that sometimes the resins themselves are part of
the problem, though additives such as dyes and antioxidants can make it
worse.
In the case of polystyrene, the resin used in styrofoam and similar
products, the authors tested 11 samples and consistently found estrogen
seepage after exposure to intense steam or ultraviolet rays.
Styrofoam is a registered trademark of Dow. The company stresses that
its product is used for crafts and building insulation, not food and
beverage containers. ("There isn't a coffee cup, cooler, or packaging
material in the world made from actual Styrofoam," according to
Dow's website.)
But generic polystyrene foam, which most people call styrofoam anyway,
is ubiquitous in the food services industry, where its found in
everything from meat trays to takeout containers. Polystyrene
resin—which the Environmental Protection Agency has labeled a suspected
carcinogen—is also used to make hard plastic items, including utensils
and toothbrushes.
The
study also looked at three different types of Tritan—a novel plastic
marketed as a safe, estrogen-free alternative to BPA-laden
polycarbonate—and found that all of them leached estrogen-like
chemicals.
That's bad news for consumers, given that hundreds of household
products are made from Tritan. Below are some examples, with the caveat
that not all of these finished products have been specifically tested
for estrogenic effects:
- CamelBak Eddy Kid's BPA-free water bottle
- CamelBak Relay water filtering pitcher
- Foogo by Thermos sippy cups
- Hamilton Beach Multi-Blend blender
- Nalgene BPA-free water bottles (color matters; see the chart below)
- OXO Good Grips LockTop food-storage containers
- Rubbermaid Hydration Chug bottles
- Rubbermaid carafes
- Rubbermaid Premier food-storage containers
- Thermos Under Armour water bottles
- Weil Baby bottles
- Weil Baby sippy cups
- Whole Foods bulk bins
The new paper was authored by University of California-Davis
toxicologist Michael Denison, who coinvented a common cell-based test
for estrogen-mimicking compounds, and by scientists from CertiChem, a
commercial lab in Austin, Texas.
As part of the study, researchers
soaked plastics resins in a variety of common solvents and tested the
chemicals that seeped out using a line of breast cancer cells (MCF-7)
that proliferates in the presence of estrogen and a line of ovarian
cancer cells (BG-1) that lights up when exposed to the female hormone.
The 200-plus samples of Tritan resins that were tested consistently
leached estrogenlike chemicals after being exposed to a type of
ultraviolet ray found in sunlight (UVA) and another kind that some
parents use to sterilize baby bottles (UVC). In some cases, samples that
hadn't even been exposed to UV light also seeped estrogenic compounds.
While the authors didn't identify the specific hormone-mimicking
chemical (or chemicals) that leached from the resin, they tested one
Tritan component—triphenyl phosphate (TPP)—and found it was estrogenic.
These findings are consistent with data collected by Tritan's
manufacturer, Tennessee-based Eastman Chemical. In 2008, the company
commissioned a study that used computer modeling to predict whether
various Tritan ingredients could imitate estrogens, based on their
chemical structures. It found that TPP was likely to be
more estrogenic than BPA. As we previously reported:
Eastman, which never disclosed these findings to its customers,
later commissioned another study, this one involving breast cancer
cells. Again, the initial results appeared positive for estrogenic
activity. In an email to colleagues, Eastman's senior toxicologist,
James Deyo, called this an "oh shit moment."
The company now says that additional testing has determined that
Tritan is not estrogenic, and insists that there is little risk of TPP
leaching from Tritan containers because it breaks down during the
manufacturing process. "We have no reason to expect TPP to be present in
the product as supplied by Eastman," says Maranda Demuth, an Eastman
spokeswoman.
But confidential documents the company filed with the US Food and
Drug Administration list TPP as one of the "substances that may be
present in food after contact with Tritan."
While the specific health effects of TPP are unknown, a 2012
literature review by a dozen prominent scientists found "substantial
evidence" that estrogen-mimicking chemicals are harmful even at minute
doses. BPA, the most studied of the lot, has been linked to myriad
problems, including asthma, cancer, infertility, low sperm count, heart
disease, and attention-deficit/hyperactivity disorder (ADHD).
In some
cases, the effects appear to be
handed down to the offspring of the person exposed.
Questions about Tritan's safety first arose in 2011, when CertiChem
scientists and V. Craig Jordan, a well-known pharmacologist and
Georgetown University professor, published a study in the National
Institutes of Health journal
Environmental Health Perspectives.
The group tested a wide variety of plastic products—including many made
from Tritan—and found that most leached estrogenic compounds when
exposed to conditions such as UV rays or heat from a microwave. These
findings touched off a fierce battle pitting the $375 billion plastics
industry against CertiChem and its founder, George Bittner, who is also a
neurobiology professor at the University of Texas-Austin. From our earlier report:
The month after Bittner's study appeared, the American Chemistry
Council contacted Chris Borgert, the former tobacco industry scientist
who stymied the EPA's Endocrine Disruptor Screening Program. According
to internal emails, the council and the Society of the Plastics Industry
offered to pay him $15,000 to write a brief letter to the journal's
editor refuting CertiChem's study…
At the same time, Eastman laid plans to sue CertiChem and PlastiPure
for false advertising. Expecting that Bittner would lash out after
being served papers, the company launched a preemptive PR blitz.
"By
proactively promoting Tritan safety," an internal memo noted, "it will
put PlastiPure in a position to have to prove Eastman wrong." The
company also paid a scientist named Thomas Osimitz $10,000 to author a
research paper on Tritan.
While Osimitz was ostensibly working
independently, Deyo, the Eastman toxicologist, micromanaged the process,
from designing the study to writing the introduction. Deyo's study
design virtually guaranteed estrogenic activity wouldn't be found.
Specifically, Deyo chose a breed of rat that doesn't readily respond
to synthetic estrogen. He also instructed the researchers to test only
select Tritan ingredients, as opposed to Tritan itself. TPP, the
chemical that had raised red flags, was not tested.
After publishing its findings in the summer of 2012, Eastman sued
CertiChem and its sister company PlastiPure for false advertising,
alleging that they were spreading false information to generate demand
for their own services.
Despite evidence that the manufacturer's own
studies found that Tritan may be estrogenic, Eastman won. A federal
judge barred the labs from discussing their Tritan findings, except in
scientific settings.
CertiChem has made good use of that exception. Earlier this year, it released a
second study
focusing on hard, clear, reusable plastic products—most of which
leached estrogenic compounds after exposure to UV rays. And some Tritan
products did so even before they were exposed to these stressors. The
chart below shows the company's results for a sampling of products.
| Product |
Type of plastic |
Before UV exposure |
After UV exposure |
| Baby bottles |
|
|
|
|
| AVENT |
Polyethersulfone (PES) |
Not tested |
Positive |
| Born Free |
Polyethersulfone (PES) |
Not tested |
Positive |
| Green to Grow |
Polyethersulfone (PES) |
Negative |
Positive |
| Evenflo |
Tritan |
Not tested |
Positive |
| Weil Baby |
Tritan |
Negative |
Positive |
| Sippy cups |
|
|
|
|
| CamelBak, blue* |
Tritan |
Positive |
Positive |
| Weil Baby |
Tritan |
Negative |
Positive |
| Water bottles |
|
|
|
|
| CamelBak, black |
Tritan |
Not tested |
Positive |
| CamelBak, blue |
Tritan |
Not tested |
Positive |
| Nalgene, blue* |
Tritan |
Negative |
Positive |
| Nalgene, green* |
Tritan |
Negative |
Negative |
| Topas |
Cyclic Olefin Copolymer (COC) |
Negative |
Negative |
| Zeonor |
Cyclic Olefin Polymer (COP) |
Negative |
Negative |
| Other products |
|
|
|
|
| Crate & Barrel wine glasses, red* |
Acrylic |
Positive |
Positive |
| Disposable cup |
Polystyrene (PS) |
Positive |
Not tested |
| Lock & Lock food containers |
Tritan |
Positive |
Positive |
| Clamshell takeout container* |
Polystyrene (PS) |
Positive |
Not tested |
*Tested using BG-1 cells
Source: George D. Bittner, et al, Environmental Health
The most recent study shows that the Tritan resin itself leaches estrogenlike chemicals, at least in a laboratory setting.
It's not all bad news, though. The paper also names a number of
resins the authors found to be free of estrogenic compounds. These
include PETG (polyethylene terephthalate, glycol-modified), which is
sometimes used in food and beverage packaging, and two relatively new
resins, COC (cyclic olefin copolymer) and COP (cyclo olefin polymer),
which are often used by the medical industry.
But Bittner, the study's lead author, warns that even products made
of those plastics aren't guaranteed to be safe, since many plastic
additives are also estrogenic. "Manufacturers don't tell the public what
additives they're using," he says. "And in most cases they're not
testing them for estrogenic activity because they don't have to. This is
a case in which the consumers are going to have to demand safer
products. If they take a stand, they can produce a very quick change in
the market. "